If you have specific help requests, come prepared with examples. A great example would be, "I really want my main page to look like ___ wikia, how did they do it?".
During Office Hours, try not to private message staff. Chances are, if you have a question, others may be interested in asking the same thing. Don't be upset if staff don't respond to your PM right away, as they'll be very busy trying to respond to everyone. Office Hours is a time for staff to be in the main conversation.
Think your wikia is already awesome? Why not share the love and stop by to provide your own tips and tricks!
Finally, here are a couple of excellent resources on Community Central to get your questions answered!